Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep916 | Neuroendocrinology | ECE2017

Secretin protects from apoptosis by activation of ERK1/2 and CREB

Wang Lei , Chow Billy

Abstract: There are a growing number of studies identifying secretin as a neuroprotective factor. Consistently, our previous data showed that neuronal apoptosis considerably increased in the developing cerebellum from secretin knockout (Sct-/-) mice. However, the underlying mechanisms remained poorly understood. Extracellular signal-regulated protein kinase (ERK) and AKT signalling pathways are known for the regulation of apoptosis. Additionally, these two pathways could activ...